An Antibody Cocktail To Lay Low A Mighty Foe

As SARS-CoV-2 variants grow in type and frequency, Covid-19 researchers are on the hunt for parts of the virus that remain consistent across variants in order to create Covid-19 treatments that work for multiple strains of the virus. This is the second in a series discussing these potential Achilles’ heels for Covid-19. Read more from this series in part one. Viruses like SARS-CoV-2, influenza, and respiratory syncytial virus, are escape artists. These viruses evade immune recognition by mutations that reduce immune recognition yet preserve the ability to infect and cause disease. SARS-CoV-2 changes many sites of the exterior spike protein to avoid neutralization, all while maintaining replication competency and in some cases, boosting competency and receptor binding avidity. However, there are some amino acids of the spike protein that are not often changed. These conserved areas may be an Achilles’ heel of the virus. Understanding these conserved regions is vital to both therapeutic and prophylactic antibody design, as well as design for future generation coronavirus vaccines. Read the full article on Forbes.
© William A. Haseltine, PhD. All Rights Reserved.