Destiny’s Child No Longer: Rewriting Genetic Fate

Destiny’s Child No Longer: Rewriting Genetic Fate invites readers to imagine a world where the genetic hand dealt at birth is no longer a fixed destiny. For millennia, our lives have been shaped by the silent lottery of DNA, a microscopic shuffle that determines health, risk, and potential before our first breath. But with the arrival of advanced genetic medicine, we now stand at the threshold of a new era, one where the mysteries of our genes can be decoded and, remarkably, rewritten.

The book opens with a vivid exploration of this transformation, blending the latest scientific breakthroughs with deeply human stories. It traces the journey from early discoveries of DNA’s structure and function, through the foundational experiments that revealed how genes are inherited and expressed, to the pioneering work that made it possible to read and now edit the genetic script. Along the way, readers meet individuals and families whose lives have been changed by both the promise and the perils of gene therapy, from the first successful treatments to the setbacks that reshaped the field’s ethical landscape.

As the narrative unfolds, Destiny’s Child No Longer examines how new tools like CRISPR and viral vectors turn science fiction into reality, offering hope for those burdened by inherited disease. Yet, it also confronts the profound ethical questions raised by this power: Will we use it wisely, ensuring equity and responsibility, or open Pandora’s box? The choice, the book argues, is both collective and individual, as we all become active participants in the story of our genetic future.

Molecular Biology of SARS-CoV-2

Offering a thorough, accessible overview of the basic science and clinical data regarding the virus that causes COVID-19, Molecular Biology of SARS-CoV-2 is an excellent resource for researchers, clinical scientists, physicians, and students. This volume offers in-depth, extended content that originated with Drs. Roberto Patarca’s and William A. Haseltine’s chapter in The COVID-19 Textbook, edited by Dr. Haseltine and Dr. Patarca. The greatly expanded material in this text provides a much-needed primer in this complex area.

Reviews the basic science, clinical data and various perspectives on how SARS-CoV-2 infects cells, replicates, manipulates cellular machinery, evades host defenses, and is transmitted to other hosts

Covers the origin and structure of SARS-CoV-2, followed by chapters based on the life cycle of the virus

Provides a thorough review of what is known for each molecular component of the viral life cycle while incorporating information on pertinent prevention and therapeutic interventions

Fusion! The Melding of Human and Machine Intelligence

Fusion! explores the groundbreaking potential of brain-machine interfaces, where human thought directly connects with technology to restore lost abilities and enhance cognitive functions. This book examines how these systems are already helping individuals with disabilities regain independence by restoring mobility and speech while enabling direct control of digital devices through thought alone.

The book provides real-world examples of brain-machine interfaces in action, showcasing their current medical and assistive technologies applications. It delves into the technical aspects of how these systems interpret complex brain signals and translate them into commands for external devices or computers. Artificial intelligence is crucial, making brain-machine interaction increasingly intuitive and seamless.

Beyond the technical promise, Fusion! Tackles critical ethical questions surrounding this emerging technology. It examines privacy, autonomy, and the implications of potentially altering cognitive functions. The book raises important considerations about who controls these powerful technologies and for what purposes they should be used

Looking to the future, the book explores how brain-machine interfaces might enhance memory, focus, and other cognitive abilities in healthy individuals. It considers the exciting possibilities and potential risks of augmenting human intelligence through direct brain-computer connections. This book is an essential read for anyone interested in the cutting-edge intersection of neuroscience, computer science, and bioengineering that is shaping the future of human-machine interaction.

Checkpoint Inhibitors: A Key to Curing Cancer

Checkpoint inhibitors have revolutionized cancer treatment since their introduction in the 2010s. This groundbreaking class of immunotherapy has given many patients extended survival and a chance at long-term remission or even cure. While powerful as standalone treatments, checkpoint inhibitors have shown even greater efficacy when combined with traditional approaches like surgery, chemotherapy, radiation, and cutting-edge therapies such as CAR T-cell therapy.

This comprehensive guide explores the science behind checkpoint inhibitors, explaining how they work to unleash the body’s immune system against cancer cells. It covers the major checkpoint inhibitors currently in use, including those targeting PD-1, PD-L1, and CTLA-4. The book also examines ongoing research into new checkpoint targets and combination strategies that could further expand the reach of these therapies.

Whether you are a patient, caregiver, healthcare professional, or simply interested in the future of cancer care, this book provides a clear and compelling overview of one of the most significant advances in oncology. It offers a glimpse into a future where checkpoint inhibitors may play a central role in turning many cancers into manageable or curable diseases.

Live Longer. What You Can Do. What Medicine Can Do.

Is aging a challenge we could navigate, delay, or even overcome? Live Longer offers a journey through cutting-edge research that transforms our thoughts about longevity. This book isn’t just a think piece; it’s a practical guide to the tools and strategies that can help us live longer, healthier lives.

Live Longer provides an accessible yet comprehensive exploration of the fundamental concepts of aging. It delves into the current understanding of the biological processes that drive aging and examines promising interventions that may slow or even reverse these processes.

The book covers a wide range of topics, including:

• The latest findings in genetics, epigenetics, and cellular biology related to aging
• Emerging therapies and interventions, from senolytics to stem cell treatments
• The role of lifestyle factors such as diet, exercise, and stress management in promoting longevity
• Potential pharmaceutical and technological approaches to extending healthspan
• Ethical considerations and societal implications of increased human lifespan

This book is an invaluable resource for anyone interested in understanding the science of aging and learning how to apply it to their lives. Whether you’re a health professional, a researcher, or simply someone looking to maximize your health span, Live Longer provides the insights and tools needed to navigate the exciting frontier of human longevity.

Better Eyesight: What You And Modern Medicine Can Do To Improve Your Vision.

From the leading edge of biotech and healthcare innovation, Dr. William A. Haseltine and Kim Hazel MPH come forth with a revolutionary resource – “Better Eyesight: What You And Modern Medicine Can Do To Improve Your Vision.” This trailblazing book maps out the vanguard of eye care technologies and treatments, offering new hope to those affected by vision issues. Better Eyesight is a valuable resource for anyone interested in eye care, whether you are a healthcare professional or just someone who wants to learn more about eye health and wellness. “Better Eyesight: What You and Modern Medicine Can Do to Improve Your Vision” illuminates modern advances in ophthalmology, including brain implants and gene therapy, and offers in-depth information on treatments such as stem cell and gene therapies for retinal disorders, laser photocoagulation, and more.

The COVID-19 Textbook: Science, Medicine, and Public Health

The COVID-19 Textbook: Science, Medicine, and Public Health explores every facet of SARS-COV-2, giving the reader an understanding of what is needed to control the spread of the virus, prevent and manage its pathological effects, as well as mitigate the impact of future pandemics. Each chapter is authored by leading global experts in the field and includes topics such as molecular biology, epidemiology, pathogenesis, immunology, diagnosis, and the latest prevention and treatment approaches. Edited by renowned educator and medical researcher Dr. William A. Haseltine, physician-researcher, and chronic fatigue syndrome expert Dr. Roberto Patarca, it includes detailed references in every chapter, allowing easy access to comprehensive primary data.

CAR T: A New Cure for Cancer, Autoimmune and Inherited Disease

For most of modern medicine, cancer drugs have been developed the same way: by designing molecules to treat diseased cells. Chimeric Antigen Receptor T cell therapy, commonly referred to as CAR T therapy, is a revolutionary cell-based immunotherapy treatment that breaks this mold. A patient’s cells are transformed through genetic engineering and reinfused into the bloodstream, allowing the cells to identify and eliminate their targets better than they naturally can. For many patients, this translates to a long-term remission or cure. As an early pioneer in cell therapies using dendritic macrophages to treat prostate cancer, Dr. William Haseltine now sees the immense potential for CAR T. In his latest book, he describes how CAR T cell therapy works, the potential and possibilities of integrating mRNA technology, current uses to treat cancer and ongoing efforts that adapt this system to treat other illnesses, including heart disease, HIV/AIDS and rheumatoid arthritis.

Ending Hepatitis C: A Seven-step Plan for a Successful Eradication Program

Just a few years ago, Egypt and the United States had approximately the same number of people infected with chronic hepatitis C. Today, Egypt has been declared virtually free of the disease, while the opioid crisis is driving an increase in hepatitis C infection rates in the United States In their latest book, Dr. William Haseltine and Kaelyn Varner, MPH, discuss lessons from the success of Egypt’s 100 Million Healthy Lives initiative and how those programs can be modified and scaled in countries of all economic levels. He identifies the seven universal traits that can be adapted to eliminate any endemic disease, such as HIV, malaria and tuberculosis, in any country. The book also provides a detailed account of the history, transmission, impact on the body, available treatments, and the ongoing efforts to eliminate this disease.

Viroids & Virusoids: Nature’s Own mRNA

Messenger RNA (mRNA) has become a key therapeutic modality. Propelled into the spotlight by the COVID-19 pandemic, vaccines are only the tip of the iceberg: there’s an mRNA revolution on the horizon. But long before mRNA was thought of as a potential therapeutic drug, nature devised its own transmissible messenger RNA: viroids and virusoids. By studying the mechanisms of these small, naked RNAs, we can learn to increase the efficiency of mRNA. In his latest book, Dr. William Haseltine explores the world of viroids and virusoids in full detail: from their potential origins in the primordial soup —roughly three to four billion years ago— to the diseases they cause and everything in between. Each step along the way is ripe with implications for fields as diverse as biomedicine and agriculture. In addition to highlighting potential futures for mRNA, the book also discusses how virusoids can help us understand and address the fatal human disease of hepatitis D.

The Future of Medicine: Healing Yourself: Regenerative Medicine

“Dr. William Haseltine first coined the term Regenerative Medicine in 1999, since then, the field has rapidly expanded. By studying our natural healing abilities, we are unlocking new ways to regenerate tissues, improve outcomes, and enhance the quality of life for people across the world. Whether it involves cell, gene, or protein therapies, or cutting-edge biomechanical interventions, regenerative medicine is revolutionizing the healthcare landscape as we know it. This book provides an overview of some of the most exciting, emerging areas of Regenerative Medicine, including DNA, antibody, and cellular therapies and organoid and transplant innovations.

Monoclonal Antibodies: The Once and Future Cure for Covid-19

“Dr. William Haseltine first coined the term Regenerative Medicine in 1999, since then, the field has rapidly expanded. By studying our natural healing abilities, we are unlocking new ways to regenerate tissues, improve outcomes, and enhance the quality of life for people across the world. Whether it involves cell, gene, or protein therapies, or cutting-edge biomechanical interventions, regenerative medicine is revolutionizing the healthcare landscape as we know it. This book provides an overview of some of the most exciting, emerging areas of Regenerative Medicine, including DNA, antibody, and cellular therapies and organoid and transplant innovations.

A Family Guide to Long Covid

“One in five adults infected with Covid-19 are now experiencing Long Covid symptoms. As more people are affected and awareness of the condition grows, many are searching for answers to their questions about Long Covid. What is Long Covid? How is it different from a Covid infection? What are the symptoms? Who is affected? How do I talk to my doctor about Long Covid? How can I advocate to get the care I need? Infectious disease expert, Dr. William Haseltine answers these questions and more in A Family Guide to Long Covid (ACCESS Health Press, July 2022). Continuing in the accessible question and answer style of the best-selling, A Family Guide to Covid the book provides straightforward answers about all aspects of Long Covid with equal measures of clarity and compassion. A Family Guide to Long Covid: Questions and Answers covers everything you need to know about Long Covid from symptoms and diagnosis to treatment and how different populations are affected. It serves as a resource that patients can use to advocate for their care and a guide for those who want to understand, prepare, and protect their families and friends.”

Omicron: From Pandemic to Endemic

Covid-19 has challenged and upended many common notions around viral infection. The Omicron variant is likely the most infectious virus since the 1918 influenza pandemic with over 200 million cases currently confirmed worldwide. As many as a third of the global population may have been infected with the Omicron variant, considering unreported cases and asymptomatic carriers. In his latest book, bestselling author William A. Haseltine and co-author Griffin McCombs offers a detailed analysis of how the Omicron variant evolved to evade our best defenses and provides a roadmap for how we might protect ourselves against future variants. Omicron: From Pandemic to Endemic (ACCESS Health Press, April 2022) collects insights from the latest research on the entire family of Omicron variants and explains the lessons that we need to implement in our public health and medical practices going forward. While many governments and citizens alike are growing weary of protective Covid-19 measures, Haseltine argues that this is not the time to let our guard down. The increasing transmissibility of the Omicron variant demonstrates the immense capacity for evolution by this virus. In terms of lethal potential, SARS-CoV-2 sits on a knife’s edge, one unlucky point mutation away from becoming substantially more dangerous.

Natural Immunity

Understanding our natural immunity to the SARS-CoV-2 virus is critical to understanding the Covid-19 pandemic and serves as a guide to what more we can do to protect ourselves. The natural immune system is what equips the body with the tools necessary to counter new threats from the microbial world and prevent severe disease. Only when these natural protections fail do we succumb to critical illness or death. How natural immunity functions has eluded our understanding—until now. This book collects insights from a fast-growing body of scientific research on the next frontier of pandemic control, not just for Covid-19 but existing and future infectious diseases. We now find ourselves in a uniquely challenging stage of the pandemic, without a long-lasting vaccine and facing a virus that evolves rapidly to become more transmissible and to defeat our best attempts at prevention and treatment. Haseltine argues that one way forward is to develop drugs that strengthen our natural immune defenses and keep vulnerable populations protected and healthy against existing and future variants. The book maps out how the body mobilizes its natural defenses against SARS-CoV-2. It also describes the virus’s extensive set of countermeasures. Strengthening the natural immune system and devising means to thwart the virus’s countermeasures opens a golden path to prevention and treatment of Covid-19.

CV-PTSD

In CV-PTSD: What It Is and What To Do About It, bestselling author William A. Haseltine gives us a name for the trauma we have experienced throughout the pandemic, both individually and collectively: Covid Related Post Traumatic Stress Disorder (CV-PTSD). In addition to outlining the shape of our shared experience, the book also lays out a comprehensive road map to help us plot a course to rebuild our societies, better and healthier than they were before./ Each chapter of the book explores the effects of the pandemic on different groups, such as schoolchildren, parents, healthcare workers, and caregivers. Taken together, the work is an urgent call to action for policymakers, healthcare leaders and patients themselves to recognize the symptoms of our shared experience and to find new opportunities to rebuild society more completely and compassionately than before. CV-PTSD is a Living eBook, updated regularly with new information as it unfolds.

Science as a Superpower

When you think about superheroes, what comes to mind? Muscle-bound men and women adorned in capes or hi-tech armor? Superhuman abilities like flying or x-ray vision? It’s unlikely you thought of people in white lab coats looking through microscopes. But in real life, science is the most powerful superpower in the world. Think about it. Scientists have used their powers to make the once impossible happen: cure diseases, extend human life, feed the world, and bring us to outer space and beyond. They are, indeed, modern-day superheroes, saving and improving millions of lives. Dr. William Haseltine discovered the power of science at an early age. And now in his latest book, Science as a Superpower: My Lifelong Fight Against Disease and the Heroes who Made it Possible, he shares his love of science with the hope of inspiring young people to pursue a life in science and someday make their own contributions to improve human life. Woven throughout are stories of his work with some of recent history’s biggest scientific heroes, and of his many successes (and failures) as he learned how to harness the superpower that is science to build a successful—and deeply impactful—career of his own./

Variants!

As the world moves into the second year of the Covid-19 pandemic, SARS-CoV-2 variants are now the fundamental issue at the root of many of our questions — Will the vaccines work? Will we need new shots each year? Will the pandemic end or can we expect a renewed surge of Covid-19 cases every year, like we see with the flu? Understanding virus variation is critical to understanding how the pandemic will unfold and how Covid-19 may continue to affect our global economy, our societies, and all of us individually. Will the current decline in new infections in the United States, for example, be permanent or a case of seasonal population immunity? These are the questions and issues at the heart of a new book by William A. Haseltine, PhD, Variants! The Shape-Shifting Challenge of COVID-19.

My Lifelong Fight Against Disease

“Place this book at the top of your list. You will be inspired to make an impact on the world, with a remarkable guide to help show you the path.”

Sanjay Gupta, MD

Associate Professor of Neurosurgery, Emory; Chief Medical Correspondent, CNN Anticipating a career in medicine, Dr. William A. Haseltine was in his first weeks of graduate studies at Harvard when a legendary physician-scientist offered this advice: “You can do more for human health through science than you ever could as a doctor.” That advice hit him “like a thunderbolt”—and he took it. Since then, Dr. Haseltine has helped combat cancers, worked to contain the HIV/AIDS pandemic and unlocked the power of the human genome to develop dozens of new pharmaceutical cures. His discoveries in molecular biology and genomics, amplified through his counsel at the highest levels of government and in the public eye, have improved the health and lives of millions of people around the world. For the first time, Dr. Haseltine tells his life story—which is still unfolding—in My Lifelong Fight Against Disease, including facing devastating public health crises such as the COVID-19 pandemic, and highlighting exhilarating moments of medical discovery. In writing the story of his wide-ranging career, Dr. Haseltine’s goals are simple: to encourage the next generation to make their own significant contribution to human life, and for all readers to appreciate science as a humanistic enterprise. A compulsively readable and fast paced insider’s account of some of the most brilliant medical breakthroughs in modern history, My Lifelong Fight Against Disease is a candid, evocative and ultimately revelatory exploration into what it means to make science your life.