How SARS-CoV-2 Evades And Suppresses The Immune System (Part 12)

Ganging up to knock out the key players

Interferon is a key player in the innate immune response. But interferon doesn’t operate in isolation. Its broad effectiveness is contingent on the recruitment of other genes. Once activated, many of these interferon-stimulated genes inhibit virus replication directly, whereas others rally the immune system’s second line of defense, the adaptive immune response, into action.

In Part 11, I examined the left half of the diagram below, which illustrates how SARS-CoV-2 blocks the induction of interferon (see Figure 1). We saw how SARS-CoV-2 blockade prevents synthesis of type-I interferons, limiting its action within the cell. Should any interferon escape suppression, other factors restrict its exit from the infected cell to alert nearby cells of impending danger.

Now we will turn to the latter half of the signaling pathway, more specifically how SARS-CoV-2 blocks induction of the interferon type-I induced genes and proteins.

Read full article on Forbes

Originally published on Forbes (September 10, 2021)

© William A. Haseltine, PhD. All Rights Reserved.